UCLA-DOE Institute

Illustrations of Amyloid Fibril structures deposited in the Protein Data Bank. Click on thumbnails below to see high resolution images of the amyloid fibril colored by residue or energy. Or download the complete atlas: colored by residue (pptx) or colored by energy (pptx). This page was last updated on April 12, 2021. 89 amyloid fibrils listed.
See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873..


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Select a method: All (89) CryoEM (65)MicroED (2)ssNMR (22)

[Mosaic Display]
Protein InformationResidue MapEnergy Map
1
Amyloid-β(1-42)
Schmidt et al., 2015
recombinant
5aefCryoEM
residues:16-40resolution:5
2
Tau 3R+4R, Alzheimer's, Paired Helical Filament
Fitzpatrick et al., 2017
extracted from brain of a human with Alzheimer's Disease
5o3lcryoEM
residues:306-378resolution:3.4
3
Tau 3R+4R, Alzheimer's, Straight Filament
Fitzpatrick et al., 2017
extracted from brain of a human with Alzheimer's Disease
5o3tcryoEM
residues:306-378resolution:3.4
4
Amyloid-β(1-42)
Gremer et al., 2017
recombinant
5oqvcryoEM
residues:1-42resolution:4
5
TDP-43 (247-257)
Guenther et al., 2018
synthetic
5w7vcryoEM
residues:247-257resolution:3.7
6
α-synuclein
Li et al., 2018
recombinant
6a6bcryoEM
residues:37-99resolution:3.1
7
α-synuclein rod polymorph
Li et al., 2018
recombinant
6cu7cryoEM
residues:38-97resolution:3.5
8
α-synuclein
Li et al., 2018
recombinant
6cu8cryoEM
residues:43-83resolution:3.6
9
Serum Amyloid A, mouse, morphology I
Liberta et al., 2019
extracted from spleen of a mouse with systemic AA amyloidosis
6dsocryoEM
residues:1-69resolution:3
10
β-2-microglobulin
Iadanza et al., 2018
recombinant
6gk3cryoEM
residues:22-85resolution:3.9
11
Tau 3R, Pick's
Falcon et al., 2018
extracted from brain of a human with Pick's Disease
6gx5cryoEM
residues:254-378 Δ275-305resolution:3.2
12
α-synuclein (1-121)
Guerrero-Ferreira et al., 2018
recombinant
6h6bcryoEM
residues:38-95resolution:3.4
13
Light Chain λ6, Antibody
Swuec et al., 2019
extracted from heart of a human with amyloid cardiomyopathy
6hudcryoEM
residues:1-37, 66-105resolution:3.3
14
Light Chain λ1, Antibody
Radamaker et al., 2019
extracted from heart of a human with cardiac AL amyloidosis
6ic3cryoEM
residues:15-105resolution:4
15
α-synuclein phospho-Y39 twist-dimer
Zhao et al., 2020b
semisynthetic
6l1tcryoEM
residues:1-100resolution:3.22
16
α-synuclein phospho-Y39 twist-trimer
Zhao et al., 2020b
semisynthetic
6l1ucryoEM
residues:1-100resolution:3.37
17
α-synuclein E46K
Zhao et al., 2020a
recombinant
6l4scryoEM
residues:45-99resolution:3.37
18
Prion (hPrP)
Wang et al., 2020
recombinant
6lnicryoEM
residues:23-231resolution:2.7
19
α-synuclein A53T
Sun et al., 2020
recombinant
6lrqcryoEM
residues:37-99resolution:3.5
20
Serum Amyloid A, human
Liberta et al., 2019
extracted from kidney of a human with AA amyloidosis
6mstcryoEM
residues:2-55resolution:2.7
Protein InformationResidue MapEnergy Map
21
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n37cryoEM
residues:312-347resolution:3.8
22
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n3acryoEM
residues:311-360resolution:3.3
23
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n3bcryoEM
residues:312-352resolution:3.8
24
TDP-43 A315E (286-331)
Cao et al., 2019
recombinant
6n3ccryoEM
residues:288-319resolution:3.3
25
Tau 4R, CTE Type 1
Falcon et al., 2019
extracted from brain of a human with Chronic Traumatic Encephalopathy
6nwpcryoEM
residues:305-379resolution:2.3
26
Tau 4R, CTE Type 2
Falcon et al., 2019
extracted from brain of a human with Chronic Traumatic Encephalopathy
6nwqcryoEM
residues:305-379resolution:3.4
27
α-synuclein N-acetylated, 1-140
Ni et al., 2019
recombinant
6osjcryoEM
residues:37-97resolution:2.8
28
α-synuclein N-acetylated, 1-122
Ni et al., 2019
recombinant
6oslcryoEM
residues:39-97resolution:3
29
α-synuclein N-acetylated, 1-103
Ni et al., 2019
recombinant
6osmcryoEM
residues:37-96resolution:3.4
30
α-synuclein H50Q
Boyer et al., 2019
recombinant
6peocryoEM
residues:36-99resolution:3.3
31
α-synuclein H50Q
Boyer et al., 2019
recombinant
6pescryoEM
residues:36-99resolution:3.6
32
Tau 4R, Snake Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjhcryoEM
residues:272-330resolution:3.3
33
Tau 4R, Twister Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjmcryoEM
residues:274-292, 304-321resolution:3.3
34
Tau 4R, Jagged Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjpcryoEM
residues:274-290, 304-321resolution:3.5
35
Tau 3R, Heparin Induced
Zhang et al., 2019
recombinant
6qjqcryoEM
residues:272-330 Δ275-305resolution:3.5
36
SH3 Domain of PI3-kinase
Röder et al., 2019
recombinant
6r4rcryoEM
residues:1-77resolution:3.4
37
α-synuclein polymorph 2a
Guerrero-Ferreira et al., 2019
recombinant
6rt0cryoEM
residues:14-25, 36-95resolution:3.1
38
α-synuclein polymorph 2b
Guerrero-Ferreira et al., 2019
recombinant
6rtbcryoEM
residues:9-24, 35-93resolution:3.5
39
Transthyretin V30M
Schmidt et al., 2019
extracted from heart of a human with hereditary V30M ATTR Amyloidosis
6sdzcryoEM
residues:11-35, 57-123resolution:3
40
Amyloid-β
Kollmer et al., 2019
extracted from brain of a human with Alzheimers Disease (meningeal tissue)
6shscryoEM
residues:1-40resolution:4.4
Protein InformationResidue MapEnergy Map
41
α-synuclein polymorph 2b
Guerrero-Ferreira et al., 2019
recombinant
6sstcryoEM
residues:14-25, 36-96resolution:3.4
42
α-synuclein polymorph 2a
Guerrero-Ferreira et al., 2019
recombinant
6ssxcryoEM
residues:14-25, 36-96resolution:3
43
Tau 4R, CBD Type 1
Zhang et al., 2020
extracted from brain of a human with Corticobasal Degeneration
6tjocryoEM
residues:274-380resolution:3.2
44
Tau 4R, CBD Type 2
Zhang et al., 2020
extracted from brain of a human with Corticobasal Degeneration
6tjxcryoEM
residues:274-380resolution:3
45
α-synuclein E46K
Boyer et al., 2020
recombinant
6ufrcryoEM
residues:36-98resolution:2.5
46
Prion (hPrP)
Glynn et al., 2020
recombinant
6uurcryoEM
residues:106-145resolution:3.5
47
Orb2
Hervás et al., 2020
extracted from Drosophila brain
6vpscryoEM
residues:176-206resolution:2.6
48
Islet Amyloid Polypeptide (IAPP) SUMO-tagged
Cao et al., 2020
recombinant
6vw2cryoEM
residues:14-37resolution:3.7
49
Amyloid-β(1-40)
Ghosh et al., 2021
seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue)
6w0ocryoEM
residues:10-40resolution:2.77
50
hnRNPA2
Lu et al., 2020
recombinant
6wqkcryoEM
residues:251-295resolution:3.1
51
FUS LC Domain
Lee et al., 2021
recombinant
6xfmcryoEM
residues:112-150resolution:2.62
52
α-synuclein MSA Case 1, Type I
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xyocryoEM
residues:14-99resolution:2.6
53
α-synuclein MSA Case 2, Type II-1
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xypcryoEM
residues:14-99resolution:3.3
54
α-synuclein MSA Case 2, Type II-2
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xyqcryoEM
residues:14-99resolution:3.1
55
Islet Amyloid Polypeptide (IAPP) C-term amidated
Roeder et al., 2020
recombinant
6y1acryoEM
residues:13-37resolution:4.2
56
Light Chain λ3, Antibody, conformation B
Radamaker et al., 2021
extracted from heart of a human with cardiac AL amyloidosis
6z1icryoEM
residues:9-49, 68-107resolution:3.4
57
Light Chain λ3, Antibody, conformation A
Radamaker et al., 2021
extracted from heart of a human with cardiac AL amyloidosis
6z1ocryoEM
residues:9-49, 60-107resolution:3.2
58
Serum Amyloid A, mouse, morphology i
Bansal et al., 2021
recombinant
6zcfcryoEM
residues:1-37resolution:2.73
59
Serum Amyloid A, mouse, morphology ii
Bansal et al., 2021
recombinant
6zcgcryoEM
residues:1-37resolution:2.95
60
Serum Amyloid A, mouse, morphology II
Bansal et al., 2021
extracted from spleen of a mouse with systemic AA amyloidosis
6zchcryoEM
residues:1-69resolution:3.5
Protein InformationResidue MapEnergy Map
61
Islet Amyloid Polypeptide (IAPP) C-term amidated
Gallardo et al., 2020
recombinant
6zrfcryoEM
residues:13-37resolution:3.6
62
Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant
Gallardo et al., 2020
recombinant
6zrqcryoEM
residues:15-37resolution:3.9
63
Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant
Gallardo et al., 2020
recombinant
6zrrcryoEM
residues:15-37resolution:4
64
hnRNPA1
Sun et al., 2020
recombinant
7bx7cryoEM
residues:251-295resolution:2.8
65
TDP-43 Low Complexity Domain (267-414)
Li et al., 2021
recombinant
7kwzcryoEM
residues:276-414resolution:3.2
66
Amyloid-β(20-34)(L-isoAsp23)
Warmack et al., 2019
synthetic
6nb9MicroED
residues:20-34resolution:1.1
67
Amyloid-β(20-34)
Warmack et al., 2019
synthetic
6oizMicroED
residues:20-34resolution:1.1
68
Amyloid-β(1-42)
Lührs et al., 2005
recombinant
2begssNMR
residues:17-42resolution:0
69
β-2-microglobulin
Iwata et al., 2006
recombinant
2e8dssNMR
residues:20-41resolution:0
70
Amyloid-β(1-40) (+)stagger
Paravastu et al., 2008
recombinant
2lmnssNMR
residues:9-40resolution:0
71
Amyloid-β(1-40) (-)stagger
Paravastu et al., 2008
recombinant
2lmossNMR
residues:9-40resolution:0
72
Amyloid-β(1-40) (+)stagger
Paravastu et al., 2008
recombinant
2lmpssNMR
residues:9-40resolution:0
73
Amyloid-β(1-40) (-)stagger
Paravastu et al., 2008
recombinant
2lmqssNMR
residues:9-40resolution:0
74
Amyloid-β(1-40) Iowa Mutation D23N
Qiang et al., 2012
recombinant
2lnqssNMR
residues:15-40resolution:0
75
Amyloid-β(1-40)
Lu et al., 2013
recombinant, seeded from brain of a human with Alzheimers Disease
2m4jssNMR
residues:1-40resolution:0
76
Amyloid-β(1-40) Iowa Mutation D23N
Sgourakis et al., 2015
recombinant
2mpzssNMR
residues:15-40resolution:0
77
Amyloid-β(1-40) E22Δ Osaka mutation
Schütz et al., 2015
recombinant
2mvxssNMR
residues:1-40resolution:0
78
Amyloid-β(1-42)
Xiao et al., 2015
recombinant
2mxussNMR
residues:11-42resolution:0
79
α-synuclein wt
Tuttle et al., 2016
recombinant
2n0assNMR
residues:43-97resolution:0
80
Amyloid-β(1-42)
Wälti et al., 2016
recombinant
2naossNMR
residues:14-42resolution:0
Protein InformationResidue MapEnergy Map
81
CA150 WW2 Domain
Ferguson et al., 2006
recombinant
2nntssNMR
residues:3-33resolution:0
82
HET-s (218-289)
Wasmer et al., 2008
recombinant
2rnmssNMR
residues:224-283resolution:0
83
Amyloid-β(1-42)
Colvin et al., 2016
recombinant
5kk3ssNMR
residues:14-42resolution:0
84
RIPK1+RIPK3
Mompeán et al., 2018
recombinant
5v7zssNMR
residues:448-462, 532-549resolution:0
85
FUS LC Domain
Murray et al., 2017
recombinant
5w3nssNMR
residues:37-97resolution:0
86
Glucagon
Gelenter et al., 2019
synthetic
6nznssNMR
residues:1-29resolution:0
87
Amyloid-β(1-40)
Cerofolini et al., 2020
recombinant
6ti5ssNMR
residues:11-40resolution:0
88
Amyloid-β(1-40 and 1-42 co-fibril)
Cerofolini et al., 2020
recombinant
6ti6ssNMR
residues:11-40, 11-42resolution:0
89
β-endorphin
Seuring et al., 2020
recombinant
6tubssNMR
residues:1-31resolution:0