UCLA-DOE Institute

Illustrations of Amyloid Fibril structures deposited in the Protein Data Bank. Click on thumbnails below to see high resolution images of the amyloid fibril colored by residue or energy. Or download the complete atlas: colored by residue (pptx) or colored by energy (pptx). This page was last updated on January 26th, 2022. 126 amyloid fibrils listed.
See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873..


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Select a method: All (126) CryoEM (101)MicroED (2)ssNMR (23)

[Mosaic Display]
Protein InformationResidue MapEnergy Map
1
Amyloid-β
Kollmer et al., 2019
extracted from brain of a human with Alzheimers Disease (meningeal tissue)
6shscryoEM
residues:1-40resolution:4.4
2
Amyloid-β(1-40 and 1-42 co-fibril)
Cerofolini et al., 2020
recombinant
6ti6ssNMR
residues:11-40, 11-42resolution:0
3
Amyloid-β(1-40)
Lu et al., 2013
recombinant, seeded from brain of a human with Alzheimers Disease
2m4jssNMR
residues:1-40resolution:0
4
Amyloid-β(1-40)
Cerofolini et al., 2020
recombinant
6ti5ssNMR
residues:11-40resolution:0
5
Amyloid-β(1-40)
Ghosh et al., 2021
seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue)
6w0ocryoEM
residues:10-40resolution:2.77
6
Amyloid-β(1-40) (+)stagger
Paravastu et al., 2008
recombinant
2lmnssNMR
residues:9-40resolution:0
7
Amyloid-β(1-40) (+)stagger
Paravastu et al., 2008
recombinant
2lmpssNMR
residues:9-40resolution:0
8
Amyloid-β(1-40) (-)stagger
Paravastu et al., 2008
recombinant
2lmossNMR
residues:9-40resolution:0
9
Amyloid-β(1-40) (-)stagger
Paravastu et al., 2008
recombinant
2lmqssNMR
residues:9-40resolution:0
10
Amyloid-β(1-40) E22Δ Osaka mutation
Schütz et al., 2015
recombinant
2mvxssNMR
residues:1-40resolution:0
11
Amyloid-β(1-40) Iowa Mutation D23N
Qiang et al., 2012
recombinant
2lnqssNMR
residues:15-40resolution:0
12
Amyloid-β(1-40) Iowa Mutation D23N
Sgourakis et al., 2015
recombinant
2mpzssNMR
residues:15-40resolution:0
13
Amyloid-β(1-42)
Lührs et al., 2005
recombinant
2begssNMR
residues:17-42resolution:0
14
Amyloid-β(1-42)
Xiao et al., 2015
recombinant
2mxussNMR
residues:11-42resolution:0
15
Amyloid-β(1-42)
Wälti et al., 2016
recombinant
2naossNMR
residues:14-42resolution:0
16
Amyloid-β(1-42)
Schmidt et al., 2015
recombinant
5aefCryoEM
residues:16-40resolution:5
17
Amyloid-β(1-42)
Colvin et al., 2016
recombinant
5kk3ssNMR
residues:14-42resolution:0
18
Amyloid-β(1-42)
Gremer et al., 2017
recombinant
5oqvcryoEM
residues:1-42resolution:4
19
Amyloid-β(1-42)
Yang et al., 2021
Type 1 fibrils extracted from the brain of a patient with Alzheimers Disease
7q4bCryoEM
residues:9-42resolution:2.5
20
Amyloid-β(1-42)
Yang et al., 2021
Type 2 fibrils extracted from the brain of a patient with Alzheimers Disease
7q4mCryoEM
residues:12-42resolution:2.8
Protein InformationResidue MapEnergy Map
21
Amyloid-β(20-34)
Warmack et al., 2019
synthetic
6oizMicroED
residues:20-34resolution:1.1
22
Amyloid-β(20-34)(L-isoAsp23)
Warmack et al., 2019
synthetic
6nb9MicroED
residues:20-34resolution:1.1
23
CA150 WW2 Domain
Ferguson et al., 2006
recombinant
2nntssNMR
residues:3-33resolution:0
24
FUS LC Domain
Murray et al., 2017
recombinant
5w3nssNMR
residues:37-97resolution:0
25
FUS LC Domain
Lee et al., 2021
recombinant
6xfmcryoEM
residues:112-150resolution:2.62
26
FUS LC Domain
Sun et al., 2021
Recombinant
7vqqCryoEM
residues:34-124resolution:2.9
27
Glucagon
Gelenter et al., 2019
synthetic
6nznssNMR
residues:1-29resolution:0
28
HET-s (218-289)
Wasmer et al., 2008
recombinant
2rnmssNMR
residues:224-283resolution:0
29
hnRNPA1
Sun et al., 2020
recombinant
7bx7cryoEM
residues:251-295resolution:2.8
30
hnRNPA2
Lu et al., 2020
recombinant
6wqkcryoEM
residues:251-295resolution:3.1
31
Islet Amyloid Polypeptide (IAPP) C-term amidated
Roeder et al., 2020
recombinant
6y1acryoEM
residues:13-37resolution:4.2
32
Islet Amyloid Polypeptide (IAPP) C-term amidated
Gallardo et al., 2020
recombinant
6zrfcryoEM
residues:13-37resolution:3.6
33
Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant
Gallardo et al., 2020
recombinant
6zrqcryoEM
residues:15-37resolution:3.9
34
Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant
Gallardo et al., 2020
recombinant
6zrrcryoEM
residues:15-37resolution:4
35
Islet Amyloid Polypeptide (IAPP) SUMO-tagged
Cao et al., 2020
recombinant
6vw2cryoEM
residues:14-37resolution:3.7
36
Islet Amyloid Polypeptide (IAPP), amidated, wild type
Cao et al., 2021
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1
7m61CryoEM
residues:13-37resolution:3.8
37
Islet Amyloid Polypeptide (IAPP), amidated, wild type
Cao et al., 2021
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2
7m62CryoEM
residues:6-37resolution:3.9
38
Islet Amyloid Polypeptide (IAPP), amidated, wild type
Cao et al., 2021
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3
7m64CryoEM
residues:13-37resolution:4
39
Islet Amyloid Polypeptide (IAPP), amidated, wild type
Cao et al., 2021
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4
7m65CryoEM
residues:6-37resolution:4.1
40
α-synuclein
Li et al., 2018
recombinant
6a6bcryoEM
residues:37-99resolution:3.1
Protein InformationResidue MapEnergy Map
41
α-synuclein
Li et al., 2018
recombinant
6cu8cryoEM
residues:43-83resolution:3.6
42
α-synuclein (1-121)
Guerrero-Ferreira et al., 2018
recombinant
6h6bcryoEM
residues:38-95resolution:3.4
43
α-synuclein A53T
Sun et al., 2020
recombinant
6lrqcryoEM
residues:37-99resolution:3.5
44
α-synuclein E46K
Zhao et al., 2020a
recombinant
6l4scryoEM
residues:45-99resolution:3.37
45
α-synuclein E46K
Boyer et al., 2020
recombinant
6ufrcryoEM
residues:36-98resolution:2.5
46
α-synuclein G51D hereditary mutation
Sun et al., 2021
Recombinant
7e0fCryoEM
residues:50-98resolution:3.02
47
α-synuclein H50Q
Boyer et al., 2019
recombinant
6peocryoEM
residues:36-99resolution:3.3
48
α-synuclein H50Q
Boyer et al., 2019
recombinant
6pescryoEM
residues:36-99resolution:3.6
49
α-synuclein MSA Case 1, Type I
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xyocryoEM
residues:14-99resolution:2.6
50
α-synuclein MSA Case 2, Type II-1
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xypcryoEM
residues:14-99resolution:3.3
51
α-synuclein MSA Case 2, Type II-2
Schweighauser et al., 2020
extracted from brain of a human with Multiple Systems Atrophy (MSA)
6xyqcryoEM
residues:14-99resolution:3.1
52
α-synuclein N-acetylated, 1-103
Ni et al., 2019
recombinant
6osmcryoEM
residues:37-96resolution:3.4
53
α-synuclein N-acetylated, 1-122
Ni et al., 2019
recombinant
6oslcryoEM
residues:39-97resolution:3
54
α-synuclein N-acetylated, 1-140
Ni et al., 2019
recombinant
6osjcryoEM
residues:37-97resolution:2.8
55
α-synuclein N-terminal Truncation 41-140
McGlinchey et al., 2021
Recombinant
7lc9CryoEM
residues:46-96resolution:3.2
56
α-synuclein phospho-Y39 twist-dimer
Zhao et al., 2020b
semisynthetic
6l1tcryoEM
residues:1-100resolution:3.22
57
α-synuclein phospho-Y39 twist-trimer
Zhao et al., 2020b
semisynthetic
6l1ucryoEM
residues:1-100resolution:3.37
58
α-synuclein polymorph 2a
Guerrero-Ferreira et al., 2019
recombinant
6rt0cryoEM
residues:14-25, 36-95resolution:3.1
59
α-synuclein polymorph 2a
Guerrero-Ferreira et al., 2019
recombinant
6ssxcryoEM
residues:14-25, 36-96resolution:3
60
α-synuclein polymorph 2b
Guerrero-Ferreira et al., 2019
recombinant
6rtbcryoEM
residues:9-24, 35-93resolution:3.5
Protein InformationResidue MapEnergy Map
61
α-synuclein polymorph 2b
Guerrero-Ferreira et al., 2019
recombinant
6sstcryoEM
residues:14-25, 36-96resolution:3.4
62
α-synuclein rod polymorph
Li et al., 2018
recombinant
6cu7cryoEM
residues:38-97resolution:3.5
63
α-synuclein Type 1A Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 2
7ncaCryoEM
residues:37-97resolution:3.47
64
α-synuclein Type 1B Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 1
7nchCryoEM
residues:14-91resolution:3.84
65
α-synuclein Type 2A Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 2
7ncgCryoEM
residues:37-97resolution:3.43
66
α-synuclein Type 2AB Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 1
7ncjCryoEM
residues:14-91resolution:4.23
67
α-synuclein Type 2B Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 1
7nciCryoEM
residues:14-91resolution:3.55
68
α-synuclein Type 3 Filaments
Lövestam et al., 2021
Recombinant, seeded from Multiple Systems Atrophy Case 5
7nckCryoEM
residues:36-99resolution:3.18
69
α-synuclein wild type
Long et al., 2021
Recombinant, seeded with E46K hereditary mutation
7c1dCryoEM
residues:46-96resolution:3.8
70
α-synuclein wt
Tuttle et al., 2016
recombinant
2n0assNMR
residues:43-97resolution:0
71
β-2-microglobulin
Iwata et al., 2006
recombinant
2e8dssNMR
residues:20-41resolution:0
72
β-2-microglobulin
Iadanza et al., 2018
recombinant
6gk3cryoEM
residues:22-85resolution:3.9
73
β-endorphin
Seuring et al., 2020
recombinant
6tubssNMR
residues:1-31resolution:0
74
Light Chain λ1, Antibody
Radamaker et al., 2019
extracted from heart of a human with cardiac AL amyloidosis
6ic3cryoEM
residues:15-105resolution:4
75
Light Chain λ3, Antibody, conformation A
Radamaker et al., 2021
Extracted from heart of a human with cardiac AL amyloidosis
6z1ocryoEM
residues:9-49, 60-107resolution:3.2
76
Light Chain λ3, Antibody, conformation B
Radamaker et al., 2021
extracted from heart of a human with cardiac AL amyloidosis
6z1icryoEM
residues:9-49, 68-107resolution:3.4
77
Light Chain λ6, Antibody
Swuec et al., 2019
extracted from heart of a human with amyloid cardiomyopathy
6hudcryoEM
residues:1-37, 66-105resolution:3.3
78
Orb2
Hervás et al., 2020
extracted from Drosophila brain
6vpscryoEM
residues:176-206resolution:2.6
79
Prion (hPrP)
Wang et al., 2020
recombinant
6lnicryoEM
residues:23-231resolution:2.7
80
Prion (hPrP)
Glynn et al., 2020
recombinant
6uurcryoEM
residues:106-145resolution:3.5
Protein InformationResidue MapEnergy Map
81
Prion (hPrP) E196K Inherited Mutation
Wang et al., 2021
Recombinant
7dwvCryoEM
residues:175-217resolution:3.07
82
Prion Protein (PrP) Syrian hamster, infectious, 263K strain
Kraus et al., 2021
Extracted from clinically ill hamster brain
7lnaCryoEM
residues:95-227resolution:3.14
83
RIPK1+RIPK3
Mompeán et al., 2018
recombinant
5v7zssNMR
residues:448-462, 532-549resolution:0
84
RIPK3 human
Wu et al., 2021
Recombinant
7da4CryoEM
residues:448-469resolution:4.24
85
RIPK3 human
Wu et al., 2021
Recombinant
7dacssNMR
residues:447-475resolution:0.01
86
Serum Amyloid A, human
Liberta et al., 2019
extracted from kidney of a human with AA amyloidosis
6mstcryoEM
residues:2-55resolution:2.7
87
Serum Amyloid A, mouse, morphology I
Liberta et al., 2019
extracted from spleen of a mouse with systemic AA amyloidosis
6dsocryoEM
residues:1-69resolution:3
88
Serum Amyloid A, mouse, morphology i
Bansal et al., 2021
recombinant
6zcfcryoEM
residues:1-37resolution:2.73
89
Serum Amyloid A, mouse, morphology ii
Bansal et al., 2021
recombinant
6zcgcryoEM
residues:1-37resolution:2.95
90
Serum Amyloid A, mouse, morphology II
Bansal et al., 2021
extracted from spleen of a mouse with systemic AA amyloidosis
6zchcryoEM
residues:1-69resolution:3.5
91
SH3 Domain of PI3-kinase
Röder et al., 2019
recombinant
6r4rcryoEM
residues:1-77resolution:3.4
92
Tau 3R+4R Paired Helical Filament
Hallinan et al., 2021
Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain
7mkfCryoEM
residues:306-378resolution:3
93
Tau 3R+4R Paired Helical Filament
Hallinan et al., 2021
Extracted from Gerstmann-Sträussler-Scheinker Patient Brain
7mkhCryoEM
residues:305-379resolution:3.3
94
Tau 3R+4R Paired Helical Filament
Shi et al., 2021
Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607
7nrvCryoEM
residues:304-330resolution:3
95
Tau 3R+4R Straight Filament
Hallinan et al., 2021
Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain
7mkgCryoEM
residues:306-378resolution:3.07
96
Tau 3R+4R Straight Filament
Shi et al., 2021
Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607
7nrxCryoEM
residues:304-380resolution:3.55
97
Tau 3R+4R Straight Filament Conformation 1
Shi et al., 2021
Extracted from Primary Age-Related Tauopathy Patient Brain Case 3
7nrsCryoEM
residues:304-380resolution:2.68
98
Tau 3R+4R Straight Filament Conformation 2
Shi et al., 2021
Extracted from Primary Age-Related Tauopathy Patient Brain Case 3
7nrtCryoEM
residues:304-380resolution:2.68
99
Tau 3R+4R, Alzheimer's, Paired Helical Filament
Fitzpatrick et al., 2017
extracted from brain of a human with Alzheimer's Disease
5o3lcryoEM
residues:306-378resolution:3.4
100
Tau 3R+4R, Alzheimer's, Straight Filament
Fitzpatrick et al., 2017
extracted from brain of a human with Alzheimer's Disease
5o3tcryoEM
residues:306-378resolution:3.4
Protein InformationResidue MapEnergy Map
101
Tau 3R, Heparin Induced
Zhang et al., 2019
recombinant
6qjqcryoEM
residues:272-330 Δ275-305resolution:3.5
102
Tau 3R, Pick's
Falcon et al., 2018
extracted from brain of a human with Pick's Disease
6gx5cryoEM
residues:254-378 Δ275-305resolution:3.2
103
Tau 4R AGD Filament Type 1
Shi et al., 2021
Extracted from Argyrophilic Grain Disease Patient Brain
7p6dCryoEM
residues:273-387resolution:3.3
104
Tau 4R AGD Filament Type 2
Shi et al., 2021
Extracted from Argyrophilic Grain Disease Patient Brain
7p6eCryoEM
residues:274-381resolution:3.4
105
Tau 4R Filament GGT Type 1
Shi et al., 2021
Extracted from Globular Glial Tauopathy Patient Brain
7p66CryoEM
residues:272-379resolution:3
106
Tau 4R Filament GGT Type 2
Shi et al., 2021
Extracted from Globular Glial Tauopathy Patient Brain
7p67CryoEM
residues:272-379resolution:3.1
107
Tau 4R Filament GGT Type 3
Shi et al., 2021
Extracted from Globular Glial Tauopathy Patient Brain
7p6aCryoEM
residues:272-379resolution:1.9
108
Tau 4R Filament LNT Type 1b
Shi et al., 2021
Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain
7p6bCryoEM
residues:272-379resolution:2.5
109
Tau 4R Filament LNT Type 2
Shi et al., 2021
Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain
7p6cCryoEM
residues:272-379resolution:2.2
110
Tau 4R PSP Filament
Shi et al., 2021
Extracted from Progressive Supranuclear Palsy Patient Brain
7p65CryoEM
residues:272-381resolution:2.7
111
Tau 4R, CBD Type 1
Zhang et al., 2020
extracted from brain of a human with Corticobasal Degeneration
6tjocryoEM
residues:274-380resolution:3.2
112
Tau 4R, CBD Type 2
Zhang et al., 2020
extracted from brain of a human with Corticobasal Degeneration
6tjxcryoEM
residues:274-380resolution:3
113
Tau 4R, CTE Type 1
Falcon et al., 2019
extracted from brain of a human with Chronic Traumatic Encephalopathy
6nwpcryoEM
residues:305-379resolution:2.3
114
Tau 4R, CTE Type 2
Falcon et al., 2019
extracted from brain of a human with Chronic Traumatic Encephalopathy
6nwqcryoEM
residues:305-379resolution:3.4
115
Tau 4R, Jagged Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjpcryoEM
residues:274-290, 304-321resolution:3.5
116
Tau 4R, Snake Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjhcryoEM
residues:272-330resolution:3.3
117
Tau 4R, Twister Polymorph, Heparin Induced
Zhang et al., 2019
recombinant
6qjmcryoEM
residues:274-292, 304-321resolution:3.3
118
TDP-43 (247-257)
Guenther et al., 2018
synthetic
5w7vcryoEM
residues:247-257resolution:3.7
119
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n37cryoEM
residues:312-347resolution:3.8
120
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n3acryoEM
residues:311-360resolution:3.3
Protein InformationResidue MapEnergy Map
121
TDP-43 (311-360)
Cao et al., 2019
recombinant
6n3bcryoEM
residues:312-352resolution:3.8
122
TDP-43 A315E (286-331)
Cao et al., 2019
recombinant
6n3ccryoEM
residues:288-319resolution:3.3
123
TDP-43 ALS and FTLD Filament
Arseni et al., 2021
Extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration
7py2CryoEM
residues:282-360resolution:2.59
124
TDP-43 Low Complexity Domain (267-414)
Li et al., 2021
recombinant
7kwzcryoEM
residues:276-414resolution:3.2
125
Transthyretin Filament from ATTR, Eye
Iakovleva et al., 2021
Extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis Patient
7ob4CryoEM
residues:11-35, 57-123resolution:3.22
126
Transthyretin V30M
Schmidt et al., 2019
extracted from heart of a human with hereditary V30M ATTR Amyloidosis
6sdzcryoEM
residues:11-35, 57-123resolution:3