| Protein Information | Residue Map | Energy Map |
---|
1 △ | Amyloid-β |
Kollmer et al., 2019 |
extracted from brain of a human with Alzheimers Disease (meningeal tissue) |
6shs | cryoEM |
residues:1-40 | resolution:4.4 |
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2 △ | |  |  |
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|
3 △ | Amyloid-β(1-40) |
Lu et al., 2013 |
recombinant, seeded from brain of a human with Alzheimers Disease |
2m4j | ssNMR |
residues:1-40 | resolution:0 |
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4 △ | |  |  |
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5 △ | Amyloid-β(1-40) |
Ghosh et al., 2021 |
seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue) |
6w0o | cryoEM |
residues:10-40 | resolution:2.77 |
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6 △ | |  |  |
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7 △ | |  |  |
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8 △ | |  |  |
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9 △ | |  |  |
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10 △ | |  |  |
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11 △ | |  |  |
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12 △ | |  |  |
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13 △ | |  |  |
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14 △ | |  |  |
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15 △ | |  |  |
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16 △ | |  |  |
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17 △ | |  |  |
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18 △ | |  |  |
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19 △ | Amyloid-β(1-42) |
Yang et al., 2021 |
Type 1 fibrils extracted from the brain of a patient with Alzheimers Disease |
7q4b | CryoEM |
residues:9-42 | resolution:2.5 |
|  |  |
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|
20 △ | Amyloid-β(1-42) |
Yang et al., 2021 |
Type 2 fibrils extracted from the brain of a patient with Alzheimers Disease |
7q4m | CryoEM |
residues:12-42 | resolution:2.8 |
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| Protein Information | Residue Map | Energy Map |
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21 △ | |  |  |
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22 △ | |  |  |
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23 △ | |  |  |
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24 △ | |  |  |
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25 △ | |  |  |
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26 △ | |  |  |
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27 △ | |  |  |
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28 △ | |  |  |
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29 △ | |  |  |
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30 △ | |  |  |
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31 △ | Islet Amyloid Polypeptide (IAPP) C-term amidated |
Roeder et al., 2020 |
recombinant |
6y1a | cryoEM |
residues:13-37 | resolution:4.2 |
|  |  |
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32 △ | |  |  |
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33 △ | Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant |
Gallardo et al., 2020 |
recombinant |
6zrq | cryoEM |
residues:15-37 | resolution:3.9 |
|  |  |
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|
34 △ | Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant |
Gallardo et al., 2020 |
recombinant |
6zrr | cryoEM |
residues:15-37 | resolution:4 |
|  |  |
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|
35 △ | Islet Amyloid Polypeptide (IAPP) SUMO-tagged |
Cao et al., 2020 |
recombinant |
6vw2 | cryoEM |
residues:14-37 | resolution:3.7 |
|  |  |
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|
36 △ | Islet Amyloid Polypeptide (IAPP), amidated, wild type |
Cao et al., 2021 |
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1 |
7m61 | CryoEM |
residues:13-37 | resolution:3.8 |
|  |  |
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|
37 △ | Islet Amyloid Polypeptide (IAPP), amidated, wild type |
Cao et al., 2021 |
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2 |
7m62 | CryoEM |
residues:6-37 | resolution:3.9 |
|  |  |
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38 △ | Islet Amyloid Polypeptide (IAPP), amidated, wild type |
Cao et al., 2021 |
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3 |
7m64 | CryoEM |
residues:13-37 | resolution:4 |
|  |  |
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|
39 △ | Islet Amyloid Polypeptide (IAPP), amidated, wild type |
Cao et al., 2021 |
Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4 |
7m65 | CryoEM |
residues:6-37 | resolution:4.1 |
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40 △ | |  |  |
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| Protein Information | Residue Map | Energy Map |
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41 △ | |  |  |
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42 △ | |  |  |
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43 △ | |  |  |
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44 △ | |  |  |
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45 △ | |  |  |
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46 △ | α-synuclein G51D hereditary mutation |
Sun et al., 2021 |
Recombinant |
7e0f | CryoEM |
residues:50-98 | resolution:3.02 |
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47 △ | |  |  |
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48 △ | |  |  |
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49 △ | α-synuclein MSA Case 1, Type I |
Schweighauser et al., 2020 |
extracted from brain of a human with Multiple Systems Atrophy (MSA) |
6xyo | cryoEM |
residues:14-99 | resolution:2.6 |
|  |  |
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|
50 △ | α-synuclein MSA Case 2, Type II-1 |
Schweighauser et al., 2020 |
extracted from brain of a human with Multiple Systems Atrophy (MSA) |
6xyp | cryoEM |
residues:14-99 | resolution:3.3 |
|  |  |
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|
51 △ | α-synuclein MSA Case 2, Type II-2 |
Schweighauser et al., 2020 |
extracted from brain of a human with Multiple Systems Atrophy (MSA) |
6xyq | cryoEM |
residues:14-99 | resolution:3.1 |
|  |  |
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|
52 △ | α-synuclein N-acetylated, 1-103 |
Ni et al., 2019 |
recombinant |
6osm | cryoEM |
residues:37-96 | resolution:3.4 |
|  |  |
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|
53 △ | α-synuclein N-acetylated, 1-122 |
Ni et al., 2019 |
recombinant |
6osl | cryoEM |
residues:39-97 | resolution:3 |
|  |  |
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|
54 △ | α-synuclein N-acetylated, 1-140 |
Ni et al., 2019 |
recombinant |
6osj | cryoEM |
residues:37-97 | resolution:2.8 |
|  |  |
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55 △ | |  |  |
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56 △ | |  |  |
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|
57 △ | α-synuclein phospho-Y39 twist-trimer |
Zhao et al., 2020b |
semisynthetic |
6l1u | cryoEM |
residues:1-100 | resolution:3.37 |
|  |  |
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58 △ | |  |  |
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59 △ | |  |  |
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60 △ | |  |  |
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| Protein Information | Residue Map | Energy Map |
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61 △ | |  |  |
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62 △ | |  |  |
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63 △ | α-synuclein Type 1A Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 2 |
7nca | CryoEM |
residues:37-97 | resolution:3.47 |
|  |  |
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|
64 △ | α-synuclein Type 1B Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 1 |
7nch | CryoEM |
residues:14-91 | resolution:3.84 |
|  |  |
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|
65 △ | α-synuclein Type 2A Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 2 |
7ncg | CryoEM |
residues:37-97 | resolution:3.43 |
|  |  |
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|
66 △ | α-synuclein Type 2AB Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 1 |
7ncj | CryoEM |
residues:14-91 | resolution:4.23 |
|  |  |
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|
67 △ | α-synuclein Type 2B Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 1 |
7nci | CryoEM |
residues:14-91 | resolution:3.55 |
|  |  |
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|
68 △ | α-synuclein Type 3 Filaments |
Lövestam et al., 2021 |
Recombinant, seeded from Multiple Systems Atrophy Case 5 |
7nck | CryoEM |
residues:36-99 | resolution:3.18 |
|  |  |
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|
69 △ | α-synuclein wild type |
Long et al., 2021 |
Recombinant, seeded with E46K hereditary mutation |
7c1d | CryoEM |
residues:46-96 | resolution:3.8 |
|  |  |
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|
70 △ | |  |  |
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71 △ | |  |  |
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72 △ | |  |  |
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73 △ | |  |  |
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|
74 △ | Light Chain λ1, Antibody |
Radamaker et al., 2019 |
extracted from heart of a human with cardiac AL amyloidosis |
6ic3 | cryoEM |
residues:15-105 | resolution:4 |
|  |  |
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|
75 △ | Light Chain λ3, Antibody, conformation A |
Radamaker et al., 2021 |
Extracted from heart of a human with cardiac AL amyloidosis |
6z1o | cryoEM |
residues:9-49, 60-107 | resolution:3.2 |
|  |  |
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|
76 △ | Light Chain λ3, Antibody, conformation B |
Radamaker et al., 2021 |
extracted from heart of a human with cardiac AL amyloidosis |
6z1i | cryoEM |
residues:9-49, 68-107 | resolution:3.4 |
|  |  |
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|
77 △ | Light Chain λ6, Antibody |
Swuec et al., 2019 |
extracted from heart of a human with amyloid cardiomyopathy |
6hud | cryoEM |
residues:1-37, 66-105 | resolution:3.3 |
|  |  |
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|
78 △ | |  |  |
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79 △ | |  |  |
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|
80 △ | |  |  |
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| Protein Information | Residue Map | Energy Map |
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81 △ | Prion (hPrP) E196K Inherited Mutation |
Wang et al., 2021 |
Recombinant |
7dwv | CryoEM |
residues:175-217 | resolution:3.07 |
|  |  |
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|
82 △ | Prion Protein (PrP) Syrian hamster, infectious, 263K strain |
Kraus et al., 2021 |
Extracted from clinically ill hamster brain |
7lna | CryoEM |
residues:95-227 | resolution:3.14 |
|  |  |
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83 △ | |  |  |
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84 △ | |  |  |
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85 △ | |  |  |
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|
86 △ | Serum Amyloid A, human |
Liberta et al., 2019 |
extracted from kidney of a human with AA amyloidosis |
6mst | cryoEM |
residues:2-55 | resolution:2.7 |
|  |  |
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|
87 △ | Serum Amyloid A, mouse, morphology I |
Liberta et al., 2019 |
extracted from spleen of a mouse with systemic AA amyloidosis |
6dso | cryoEM |
residues:1-69 | resolution:3 |
|  |  |
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88 △ | |  |  |
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89 △ | |  |  |
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|
90 △ | Serum Amyloid A, mouse, morphology II |
Bansal et al., 2021 |
extracted from spleen of a mouse with systemic AA amyloidosis |
6zch | cryoEM |
residues:1-69 | resolution:3.5 |
|  |  |
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91 △ | |  |  |
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|
92 △ | Tau 3R+4R Paired Helical Filament |
Hallinan et al., 2021 |
Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain |
7mkf | CryoEM |
residues:306-378 | resolution:3 |
|  |  |
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|
93 △ | Tau 3R+4R Paired Helical Filament |
Hallinan et al., 2021 |
Extracted from Gerstmann-Sträussler-Scheinker Patient Brain |
7mkh | CryoEM |
residues:305-379 | resolution:3.3 |
|  |  |
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|
94 △ | Tau 3R+4R Paired Helical Filament |
Shi et al., 2021 |
Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607 |
7nrv | CryoEM |
residues:304-330 | resolution:3 |
|  |  |
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|
95 △ | Tau 3R+4R Straight Filament |
Hallinan et al., 2021 |
Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain |
7mkg | CryoEM |
residues:306-378 | resolution:3.07 |
|  |  |
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|
96 △ | Tau 3R+4R Straight Filament |
Shi et al., 2021 |
Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607 |
7nrx | CryoEM |
residues:304-380 | resolution:3.55 |
|  |  |
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|
97 △ | Tau 3R+4R Straight Filament Conformation 1 |
Shi et al., 2021 |
Extracted from Primary Age-Related Tauopathy Patient Brain Case 3 |
7nrs | CryoEM |
residues:304-380 | resolution:2.68 |
|  |  |
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|
98 △ | Tau 3R+4R Straight Filament Conformation 2 |
Shi et al., 2021 |
Extracted from Primary Age-Related Tauopathy Patient Brain Case 3 |
7nrt | CryoEM |
residues:304-380 | resolution:2.68 |
|  |  |
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|
99 △ | Tau 3R+4R, Alzheimer's, Paired Helical Filament |
Fitzpatrick et al., 2017 |
extracted from brain of a human with Alzheimer's Disease |
5o3l | cryoEM |
residues:306-378 | resolution:3.4 |
|  |  |
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|
100 △ | Tau 3R+4R, Alzheimer's, Straight Filament |
Fitzpatrick et al., 2017 |
extracted from brain of a human with Alzheimer's Disease |
5o3t | cryoEM |
residues:306-378 | resolution:3.4 |
|  |  |
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|
| Protein Information | Residue Map | Energy Map |
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101 △ | |  |  |
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|
102 △ | Tau 3R, Pick's |
Falcon et al., 2018 |
extracted from brain of a human with Pick's Disease |
6gx5 | cryoEM |
residues:254-378 Δ275-305 | resolution:3.2 |
|  |  |
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|
103 △ | Tau 4R AGD Filament Type 1 |
Shi et al., 2021 |
Extracted from Argyrophilic Grain Disease Patient Brain |
7p6d | CryoEM |
residues:273-387 | resolution:3.3 |
|  |  |
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|
104 △ | Tau 4R AGD Filament Type 2 |
Shi et al., 2021 |
Extracted from Argyrophilic Grain Disease Patient Brain |
7p6e | CryoEM |
residues:274-381 | resolution:3.4 |
|  |  |
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|
105 △ | Tau 4R Filament GGT Type 1 |
Shi et al., 2021 |
Extracted from Globular Glial Tauopathy Patient Brain |
7p66 | CryoEM |
residues:272-379 | resolution:3 |
|  |  |
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|
106 △ | Tau 4R Filament GGT Type 2 |
Shi et al., 2021 |
Extracted from Globular Glial Tauopathy Patient Brain |
7p67 | CryoEM |
residues:272-379 | resolution:3.1 |
|  |  |
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|
107 △ | Tau 4R Filament GGT Type 3 |
Shi et al., 2021 |
Extracted from Globular Glial Tauopathy Patient Brain |
7p6a | CryoEM |
residues:272-379 | resolution:1.9 |
|  |  |
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|
108 △ | Tau 4R Filament LNT Type 1b |
Shi et al., 2021 |
Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain |
7p6b | CryoEM |
residues:272-379 | resolution:2.5 |
|  |  |
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|
109 △ | Tau 4R Filament LNT Type 2 |
Shi et al., 2021 |
Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain |
7p6c | CryoEM |
residues:272-379 | resolution:2.2 |
|  |  |
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|
110 △ | Tau 4R PSP Filament |
Shi et al., 2021 |
Extracted from Progressive Supranuclear Palsy Patient Brain |
7p65 | CryoEM |
residues:272-381 | resolution:2.7 |
|  |  |
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|
111 △ | Tau 4R, CBD Type 1 |
Zhang et al., 2020 |
extracted from brain of a human with Corticobasal Degeneration |
6tjo | cryoEM |
residues:274-380 | resolution:3.2 |
|  |  |
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|
112 △ | Tau 4R, CBD Type 2 |
Zhang et al., 2020 |
extracted from brain of a human with Corticobasal Degeneration |
6tjx | cryoEM |
residues:274-380 | resolution:3 |
|  |  |
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|
113 △ | Tau 4R, CTE Type 1 |
Falcon et al., 2019 |
extracted from brain of a human with Chronic Traumatic Encephalopathy |
6nwp | cryoEM |
residues:305-379 | resolution:2.3 |
|  |  |
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|
114 △ | Tau 4R, CTE Type 2 |
Falcon et al., 2019 |
extracted from brain of a human with Chronic Traumatic Encephalopathy |
6nwq | cryoEM |
residues:305-379 | resolution:3.4 |
|  |  |
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|
115 △ | Tau 4R, Jagged Polymorph, Heparin Induced |
Zhang et al., 2019 |
recombinant |
6qjp | cryoEM |
residues:274-290, 304-321 | resolution:3.5 |
|  |  |
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|
116 △ | Tau 4R, Snake Polymorph, Heparin Induced |
Zhang et al., 2019 |
recombinant |
6qjh | cryoEM |
residues:272-330 | resolution:3.3 |
|  |  |
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|
117 △ | Tau 4R, Twister Polymorph, Heparin Induced |
Zhang et al., 2019 |
recombinant |
6qjm | cryoEM |
residues:274-292, 304-321 | resolution:3.3 |
|  |  |
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|
118 △ | |  |  |
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|
119 △ | |  |  |
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|
120 △ | |  |  |
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|
| Protein Information | Residue Map | Energy Map |
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121 △ | |  |  |
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|
122 △ | |  |  |
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|
123 △ | TDP-43 ALS and FTLD Filament |
Arseni et al., 2021 |
Extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration |
7py2 | CryoEM |
residues:282-360 | resolution:2.59 |
|  |  |
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|
124 △ | TDP-43 Low Complexity Domain (267-414) |
Li et al., 2021 |
recombinant |
7kwz | cryoEM |
residues:276-414 | resolution:3.2 |
|  |  |
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|
125 △ | Transthyretin Filament from ATTR, Eye |
Iakovleva et al., 2021 |
Extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis Patient |
7ob4 | CryoEM |
residues:11-35, 57-123 | resolution:3.22 |
|  |  |
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|
126 △ | Transthyretin V30M |
Schmidt et al., 2019 |
extracted from heart of a human with hereditary V30M ATTR Amyloidosis |
6sdz | cryoEM |
residues:11-35, 57-123 | resolution:3 |
|  |  |
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|