Illustrations of Amyloid Fibril structures deposited in the Protein Data Bank. Click on thumbnails below to see high resolution images of the amyloid fibril colored by residue or energy. Or download the complete atlas: colored by residue (pptx) or colored by energy (pptx). This page was last updated on January 26th, 2022. 126 amyloid fibrils listed.
See our accompanying review: The expanding amyloid family: Structure, stability, function, and pathogenesis, Cell, Vol 184, Issue 19, Sept. 16, 2021, pp. 4857-4873..

	Protein Information	Residue Map	Energy Map
1 △	Amyloid-β Kollmer et al., 2019 extracted from brain of a human with Alzheimers Disease (meningeal tissue) 6shs cryoEM residues:1-40 resolution:4.4
2 △	Amyloid-β(1-40 and 1-42 co-fibril) Cerofolini et al., 2020 recombinant 6ti6 ssNMR residues:11-40, 11-42 resolution:0
3 △	Amyloid-β(1-40) Lu et al., 2013 recombinant, seeded from brain of a human with Alzheimers Disease 2m4j ssNMR residues:1-40 resolution:0
4 △	Amyloid-β(1-40) Cerofolini et al., 2020 recombinant 6ti5 ssNMR residues:11-40 resolution:0
5 △	Amyloid-β(1-40) Ghosh et al., 2021 seeded with fibrils extracted from brain of a human with Alzheimers Disease (cortical tissue) 6w0o cryoEM residues:10-40 resolution:2.77
6 △	Amyloid-β(1-40) (+)stagger Paravastu et al., 2008 recombinant 2lmn ssNMR residues:9-40 resolution:0
7 △	Amyloid-β(1-40) (+)stagger Paravastu et al., 2008 recombinant 2lmp ssNMR residues:9-40 resolution:0
8 △	Amyloid-β(1-40) (-)stagger Paravastu et al., 2008 recombinant 2lmo ssNMR residues:9-40 resolution:0
9 △	Amyloid-β(1-40) (-)stagger Paravastu et al., 2008 recombinant 2lmq ssNMR residues:9-40 resolution:0
10 △	Amyloid-β(1-40) E22Δ Osaka mutation Schütz et al., 2015 recombinant 2mvx ssNMR residues:1-40 resolution:0
11 △	Amyloid-β(1-40) Iowa Mutation D23N Qiang et al., 2012 recombinant 2lnq ssNMR residues:15-40 resolution:0
12 △	Amyloid-β(1-40) Iowa Mutation D23N Sgourakis et al., 2015 recombinant 2mpz ssNMR residues:15-40 resolution:0
13 △	Amyloid-β(1-42) Lührs et al., 2005 recombinant 2beg ssNMR residues:17-42 resolution:0
14 △	Amyloid-β(1-42) Xiao et al., 2015 recombinant 2mxu ssNMR residues:11-42 resolution:0
15 △	Amyloid-β(1-42) Wälti et al., 2016 recombinant 2nao ssNMR residues:14-42 resolution:0
16 △	Amyloid-β(1-42) Schmidt et al., 2015 recombinant 5aef CryoEM residues:16-40 resolution:5
17 △	Amyloid-β(1-42) Colvin et al., 2016 recombinant 5kk3 ssNMR residues:14-42 resolution:0
18 △	Amyloid-β(1-42) Gremer et al., 2017 recombinant 5oqv cryoEM residues:1-42 resolution:4
19 △	Amyloid-β(1-42) Yang et al., 2021 Type 1 fibrils extracted from the brain of a patient with Alzheimers Disease 7q4b CryoEM residues:9-42 resolution:2.5
20 △	Amyloid-β(1-42) Yang et al., 2021 Type 2 fibrils extracted from the brain of a patient with Alzheimers Disease 7q4m CryoEM residues:12-42 resolution:2.8
	Protein Information	Residue Map	Energy Map
21 △	Amyloid-β(20-34) Warmack et al., 2019 synthetic 6oiz MicroED residues:20-34 resolution:1.1
22 △	Amyloid-β(20-34)(L-isoAsp23) Warmack et al., 2019 synthetic 6nb9 MicroED residues:20-34 resolution:1.1
23 △	CA150 WW2 Domain Ferguson et al., 2006 recombinant 2nnt ssNMR residues:3-33 resolution:0
24 △	FUS LC Domain Murray et al., 2017 recombinant 5w3n ssNMR residues:37-97 resolution:0
25 △	FUS LC Domain Lee et al., 2021 recombinant 6xfm cryoEM residues:112-150 resolution:2.62
26 △	FUS LC Domain Sun et al., 2021 Recombinant 7vqq CryoEM residues:34-124 resolution:2.9
27 △	Glucagon Gelenter et al., 2019 synthetic 6nzn ssNMR residues:1-29 resolution:0
28 △	HET-s (218-289) Wasmer et al., 2008 recombinant 2rnm ssNMR residues:224-283 resolution:0
29 △	hnRNPA1 Sun et al., 2020 recombinant 7bx7 cryoEM residues:251-295 resolution:2.8
30 △	hnRNPA2 Lu et al., 2020 recombinant 6wqk cryoEM residues:251-295 resolution:3.1
31 △	Islet Amyloid Polypeptide (IAPP) C-term amidated Roeder et al., 2020 recombinant 6y1a cryoEM residues:13-37 resolution:4.2
32 △	Islet Amyloid Polypeptide (IAPP) C-term amidated Gallardo et al., 2020 recombinant 6zrf cryoEM residues:13-37 resolution:3.6
33 △	Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant Gallardo et al., 2020 recombinant 6zrq cryoEM residues:15-37 resolution:3.9
34 △	Islet Amyloid Polypeptide (IAPP) C-term amidated S20G mutant Gallardo et al., 2020 recombinant 6zrr cryoEM residues:15-37 resolution:4
35 △	Islet Amyloid Polypeptide (IAPP) SUMO-tagged Cao et al., 2020 recombinant 6vw2 cryoEM residues:14-37 resolution:3.7
36 △	Islet Amyloid Polypeptide (IAPP), amidated, wild type Cao et al., 2021 Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 1 7m61 CryoEM residues:13-37 resolution:3.8
37 △	Islet Amyloid Polypeptide (IAPP), amidated, wild type Cao et al., 2021 Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 2 7m62 CryoEM residues:6-37 resolution:3.9
38 △	Islet Amyloid Polypeptide (IAPP), amidated, wild type Cao et al., 2021 Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 3 7m64 CryoEM residues:13-37 resolution:4
39 △	Islet Amyloid Polypeptide (IAPP), amidated, wild type Cao et al., 2021 Synthetic, seeded with fibrils from a Type 2 Diabetes Patient, Polymorph 4 7m65 CryoEM residues:6-37 resolution:4.1
40 △	α-synuclein Li et al., 2018 recombinant 6a6b cryoEM residues:37-99 resolution:3.1
	Protein Information	Residue Map	Energy Map
41 △	α-synuclein Li et al., 2018 recombinant 6cu8 cryoEM residues:43-83 resolution:3.6
42 △	α-synuclein (1-121) Guerrero-Ferreira et al., 2018 recombinant 6h6b cryoEM residues:38-95 resolution:3.4
43 △	α-synuclein A53T Sun et al., 2020 recombinant 6lrq cryoEM residues:37-99 resolution:3.5
44 △	α-synuclein E46K Zhao et al., 2020a recombinant 6l4s cryoEM residues:45-99 resolution:3.37
45 △	α-synuclein E46K Boyer et al., 2020 recombinant 6ufr cryoEM residues:36-98 resolution:2.5
46 △	α-synuclein G51D hereditary mutation Sun et al., 2021 Recombinant 7e0f CryoEM residues:50-98 resolution:3.02
47 △	α-synuclein H50Q Boyer et al., 2019 recombinant 6peo cryoEM residues:36-99 resolution:3.3
48 △	α-synuclein H50Q Boyer et al., 2019 recombinant 6pes cryoEM residues:36-99 resolution:3.6
49 △	α-synuclein MSA Case 1, Type I Schweighauser et al., 2020 extracted from brain of a human with Multiple Systems Atrophy (MSA) 6xyo cryoEM residues:14-99 resolution:2.6
50 △	α-synuclein MSA Case 2, Type II-1 Schweighauser et al., 2020 extracted from brain of a human with Multiple Systems Atrophy (MSA) 6xyp cryoEM residues:14-99 resolution:3.3
51 △	α-synuclein MSA Case 2, Type II-2 Schweighauser et al., 2020 extracted from brain of a human with Multiple Systems Atrophy (MSA) 6xyq cryoEM residues:14-99 resolution:3.1
52 △	α-synuclein N-acetylated, 1-103 Ni et al., 2019 recombinant 6osm cryoEM residues:37-96 resolution:3.4
53 △	α-synuclein N-acetylated, 1-122 Ni et al., 2019 recombinant 6osl cryoEM residues:39-97 resolution:3
54 △	α-synuclein N-acetylated, 1-140 Ni et al., 2019 recombinant 6osj cryoEM residues:37-97 resolution:2.8
55 △	α-synuclein N-terminal Truncation 41-140 McGlinchey et al., 2021 Recombinant 7lc9 CryoEM residues:46-96 resolution:3.2
56 △	α-synuclein phospho-Y39 twist-dimer Zhao et al., 2020b semisynthetic 6l1t cryoEM residues:1-100 resolution:3.22
57 △	α-synuclein phospho-Y39 twist-trimer Zhao et al., 2020b semisynthetic 6l1u cryoEM residues:1-100 resolution:3.37
58 △	α-synuclein polymorph 2a Guerrero-Ferreira et al., 2019 recombinant 6rt0 cryoEM residues:14-25, 36-95 resolution:3.1
59 △	α-synuclein polymorph 2a Guerrero-Ferreira et al., 2019 recombinant 6ssx cryoEM residues:14-25, 36-96 resolution:3
60 △	α-synuclein polymorph 2b Guerrero-Ferreira et al., 2019 recombinant 6rtb cryoEM residues:9-24, 35-93 resolution:3.5
	Protein Information	Residue Map	Energy Map
61 △	α-synuclein polymorph 2b Guerrero-Ferreira et al., 2019 recombinant 6sst cryoEM residues:14-25, 36-96 resolution:3.4
62 △	α-synuclein rod polymorph Li et al., 2018 recombinant 6cu7 cryoEM residues:38-97 resolution:3.5
63 △	α-synuclein Type 1A Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 2 7nca CryoEM residues:37-97 resolution:3.47
64 △	α-synuclein Type 1B Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 1 7nch CryoEM residues:14-91 resolution:3.84
65 △	α-synuclein Type 2A Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 2 7ncg CryoEM residues:37-97 resolution:3.43
66 △	α-synuclein Type 2AB Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 1 7ncj CryoEM residues:14-91 resolution:4.23
67 △	α-synuclein Type 2B Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 1 7nci CryoEM residues:14-91 resolution:3.55
68 △	α-synuclein Type 3 Filaments Lövestam et al., 2021 Recombinant, seeded from Multiple Systems Atrophy Case 5 7nck CryoEM residues:36-99 resolution:3.18
69 △	α-synuclein wild type Long et al., 2021 Recombinant, seeded with E46K hereditary mutation 7c1d CryoEM residues:46-96 resolution:3.8
70 △	α-synuclein wt Tuttle et al., 2016 recombinant 2n0a ssNMR residues:43-97 resolution:0
71 △	β-2-microglobulin Iwata et al., 2006 recombinant 2e8d ssNMR residues:20-41 resolution:0
72 △	β-2-microglobulin Iadanza et al., 2018 recombinant 6gk3 cryoEM residues:22-85 resolution:3.9
73 △	β-endorphin Seuring et al., 2020 recombinant 6tub ssNMR residues:1-31 resolution:0
74 △	Light Chain λ1, Antibody Radamaker et al., 2019 extracted from heart of a human with cardiac AL amyloidosis 6ic3 cryoEM residues:15-105 resolution:4
75 △	Light Chain λ3, Antibody, conformation A Radamaker et al., 2021 Extracted from heart of a human with cardiac AL amyloidosis 6z1o cryoEM residues:9-49, 60-107 resolution:3.2
76 △	Light Chain λ3, Antibody, conformation B Radamaker et al., 2021 extracted from heart of a human with cardiac AL amyloidosis 6z1i cryoEM residues:9-49, 68-107 resolution:3.4
77 △	Light Chain λ6, Antibody Swuec et al., 2019 extracted from heart of a human with amyloid cardiomyopathy 6hud cryoEM residues:1-37, 66-105 resolution:3.3
78 △	Orb2 Hervás et al., 2020 extracted from Drosophila brain 6vps cryoEM residues:176-206 resolution:2.6
79 △	Prion (hPrP) Wang et al., 2020 recombinant 6lni cryoEM residues:23-231 resolution:2.7
80 △	Prion (hPrP) Glynn et al., 2020 recombinant 6uur cryoEM residues:106-145 resolution:3.5
	Protein Information	Residue Map	Energy Map
81 △	Prion (hPrP) E196K Inherited Mutation Wang et al., 2021 Recombinant 7dwv CryoEM residues:175-217 resolution:3.07
82 △	Prion Protein (PrP) Syrian hamster, infectious, 263K strain Kraus et al., 2021 Extracted from clinically ill hamster brain 7lna CryoEM residues:95-227 resolution:3.14
83 △	RIPK1+RIPK3 Mompeán et al., 2018 recombinant 5v7z ssNMR residues:448-462, 532-549 resolution:0
84 △	RIPK3 human Wu et al., 2021 Recombinant 7da4 CryoEM residues:448-469 resolution:4.24
85 △	RIPK3 human Wu et al., 2021 Recombinant 7dac ssNMR residues:447-475 resolution:0.01
86 △	Serum Amyloid A, human Liberta et al., 2019 extracted from kidney of a human with AA amyloidosis 6mst cryoEM residues:2-55 resolution:2.7
87 △	Serum Amyloid A, mouse, morphology I Liberta et al., 2019 extracted from spleen of a mouse with systemic AA amyloidosis 6dso cryoEM residues:1-69 resolution:3
88 △	Serum Amyloid A, mouse, morphology i Bansal et al., 2021 recombinant 6zcf cryoEM residues:1-37 resolution:2.73
89 △	Serum Amyloid A, mouse, morphology ii Bansal et al., 2021 recombinant 6zcg cryoEM residues:1-37 resolution:2.95
90 △	Serum Amyloid A, mouse, morphology II Bansal et al., 2021 extracted from spleen of a mouse with systemic AA amyloidosis 6zch cryoEM residues:1-69 resolution:3.5
91 △	SH3 Domain of PI3-kinase Röder et al., 2019 recombinant 6r4r cryoEM residues:1-77 resolution:3.4
92 △	Tau 3R+4R Paired Helical Filament Hallinan et al., 2021 Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain 7mkf CryoEM residues:306-378 resolution:3
93 △	Tau 3R+4R Paired Helical Filament Hallinan et al., 2021 Extracted from Gerstmann-Sträussler-Scheinker Patient Brain 7mkh CryoEM residues:305-379 resolution:3.3
94 △	Tau 3R+4R Paired Helical Filament Shi et al., 2021 Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607 7nrv CryoEM residues:304-330 resolution:3
95 △	Tau 3R+4R Straight Filament Hallinan et al., 2021 Extracted from PrP Cerebral Amyloid Angiopathy Patient Brain 7mkg CryoEM residues:306-378 resolution:3.07
96 △	Tau 3R+4R Straight Filament Shi et al., 2021 Extracted from Alzheimers Patient Brain and Stained with PET ligand APN1607 7nrx CryoEM residues:304-380 resolution:3.55
97 △	Tau 3R+4R Straight Filament Conformation 1 Shi et al., 2021 Extracted from Primary Age-Related Tauopathy Patient Brain Case 3 7nrs CryoEM residues:304-380 resolution:2.68
98 △	Tau 3R+4R Straight Filament Conformation 2 Shi et al., 2021 Extracted from Primary Age-Related Tauopathy Patient Brain Case 3 7nrt CryoEM residues:304-380 resolution:2.68
99 △	Tau 3R+4R, Alzheimer's, Paired Helical Filament Fitzpatrick et al., 2017 extracted from brain of a human with Alzheimer's Disease 5o3l cryoEM residues:306-378 resolution:3.4
100 △	Tau 3R+4R, Alzheimer's, Straight Filament Fitzpatrick et al., 2017 extracted from brain of a human with Alzheimer's Disease 5o3t cryoEM residues:306-378 resolution:3.4
	Protein Information	Residue Map	Energy Map
101 △	Tau 3R, Heparin Induced Zhang et al., 2019 recombinant 6qjq cryoEM residues:272-330 Δ275-305 resolution:3.5
102 △	Tau 3R, Pick's Falcon et al., 2018 extracted from brain of a human with Pick's Disease 6gx5 cryoEM residues:254-378 Δ275-305 resolution:3.2
103 △	Tau 4R AGD Filament Type 1 Shi et al., 2021 Extracted from Argyrophilic Grain Disease Patient Brain 7p6d CryoEM residues:273-387 resolution:3.3
104 △	Tau 4R AGD Filament Type 2 Shi et al., 2021 Extracted from Argyrophilic Grain Disease Patient Brain 7p6e CryoEM residues:274-381 resolution:3.4
105 △	Tau 4R Filament GGT Type 1 Shi et al., 2021 Extracted from Globular Glial Tauopathy Patient Brain 7p66 CryoEM residues:272-379 resolution:3
106 △	Tau 4R Filament GGT Type 2 Shi et al., 2021 Extracted from Globular Glial Tauopathy Patient Brain 7p67 CryoEM residues:272-379 resolution:3.1
107 △	Tau 4R Filament GGT Type 3 Shi et al., 2021 Extracted from Globular Glial Tauopathy Patient Brain 7p6a CryoEM residues:272-379 resolution:1.9
108 △	Tau 4R Filament LNT Type 1b Shi et al., 2021 Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain 7p6b CryoEM residues:272-379 resolution:2.5
109 △	Tau 4R Filament LNT Type 2 Shi et al., 2021 Extracted from Limbic-Predominant Neuronal Inclusion Body 4R Tauopathy Patient Brain 7p6c CryoEM residues:272-379 resolution:2.2
110 △	Tau 4R PSP Filament Shi et al., 2021 Extracted from Progressive Supranuclear Palsy Patient Brain 7p65 CryoEM residues:272-381 resolution:2.7
111 △	Tau 4R, CBD Type 1 Zhang et al., 2020 extracted from brain of a human with Corticobasal Degeneration 6tjo cryoEM residues:274-380 resolution:3.2
112 △	Tau 4R, CBD Type 2 Zhang et al., 2020 extracted from brain of a human with Corticobasal Degeneration 6tjx cryoEM residues:274-380 resolution:3
113 △	Tau 4R, CTE Type 1 Falcon et al., 2019 extracted from brain of a human with Chronic Traumatic Encephalopathy 6nwp cryoEM residues:305-379 resolution:2.3
114 △	Tau 4R, CTE Type 2 Falcon et al., 2019 extracted from brain of a human with Chronic Traumatic Encephalopathy 6nwq cryoEM residues:305-379 resolution:3.4
115 △	Tau 4R, Jagged Polymorph, Heparin Induced Zhang et al., 2019 recombinant 6qjp cryoEM residues:274-290, 304-321 resolution:3.5
116 △	Tau 4R, Snake Polymorph, Heparin Induced Zhang et al., 2019 recombinant 6qjh cryoEM residues:272-330 resolution:3.3
117 △	Tau 4R, Twister Polymorph, Heparin Induced Zhang et al., 2019 recombinant 6qjm cryoEM residues:274-292, 304-321 resolution:3.3
118 △	TDP-43 (247-257) Guenther et al., 2018 synthetic 5w7v cryoEM residues:247-257 resolution:3.7
119 △	TDP-43 (311-360) Cao et al., 2019 recombinant 6n37 cryoEM residues:312-347 resolution:3.8
120 △	TDP-43 (311-360) Cao et al., 2019 recombinant 6n3a cryoEM residues:311-360 resolution:3.3
	Protein Information	Residue Map	Energy Map
121 △	TDP-43 (311-360) Cao et al., 2019 recombinant 6n3b cryoEM residues:312-352 resolution:3.8
122 △	TDP-43 A315E (286-331) Cao et al., 2019 recombinant 6n3c cryoEM residues:288-319 resolution:3.3
123 △	TDP-43 ALS and FTLD Filament Arseni et al., 2021 Extracted from Patient with Amyotrophic Lateral Sclerosis and Fronto-temporal Lobar Degeneration 7py2 CryoEM residues:282-360 resolution:2.59
124 △	TDP-43 Low Complexity Domain (267-414) Li et al., 2021 recombinant 7kwz cryoEM residues:276-414 resolution:3.2
125 △	Transthyretin Filament from ATTR, Eye Iakovleva et al., 2021 Extracted from the Vitreous Body of the Eye of an Amyloid Transthyretin Amyloidosis Patient 7ob4 CryoEM residues:11-35, 57-123 resolution:3.22
126 △	Transthyretin V30M Schmidt et al., 2019 extracted from heart of a human with hereditary V30M ATTR Amyloidosis 6sdz cryoEM residues:11-35, 57-123 resolution:3